Mlb Opening Day 2025 Schedule Dates. Baseball's traditional opening day will feature five interleague series and four division series. From the tokyo series and opening day through the end of the regular season, here are the key dates to know on the 2025 mlb schedule.

Here’s a look at the 2025 opening day schedule for thursday, march 27. The 15 games on traditional opening day will feature four divisional matchups and five interleague contests.